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Remdesivir mantiene la actividad antiviral contra ómicron y otras variantes en estudios 'in vitro' Remdesivir mantiene la actividad antiviral contra ómicron y otras variantes
Gilead Sciences ha publicado datos que demuestran la actividad 'in vitro' de 'Veklury' (remdesivir) contra diez variantes del SARS-CoV-2, incluida ómicron. Los resultados de los estudios de Gilead coinciden con otros estudios 'in vitro' realizados de forma independiente por investigadores de instituciones de otros países, como Bélgica, República Checa, Alemania, Polonia y Estados Unidos, que confirmaron la actividad antiviral de 'Veklury' contra múltiples variantes del SARS-CoV-2 previamente identificadas, entre ellas Alfa, Beta, Gamma, Delta y ómicron.
Analizadas diez variantes del covid El estudio analizó la actividad antiviral 'in vitro' mediante dos métodos para comprender la susceptibilidad de diez variantes principales del SARS-CoV-2 al fármaco . Los resultados del estudio mostraron una actividad similar de la terapia contra las variantes y un aislado del linaje A ancestral temprano detectado en Seattle (cepa WA1).
En concreto, las variantes Delta y ómicron siguieron siendo totalmente susceptibles al antiviral, y estos resultados de laboratorio demuestran que ha seguido siendo activo contra todas las variantes principales aisladas en los últimos dos años.
El antiviral inhibe directamente la replicación del virus dentro de las células del huésped al dirigirse a la ARN polimerasa dependiente del ARN del covid. Al entrar en el organismo, el fármaco se transforma en el metabolito trifosfato activo, que se incorpora al ARN viral y detiene la replicación del virus dentro de las células infectadas.
El estudio analizó casi 6 millones de secuencias de variantes aisladas disponibles públicamente y confirmó que la proteína nsp12, la diana de la ARN polimerasa del antiviral, está bien conservada para todas las variantes. Una caracterización más detallada confirmó que ninguna de las pocas mutaciones identificadas de nsp12 que prevalecen en algunas de las variantes del SARS-CoV-2 afecta a la susceptibilidad del virus al tratamiento.
Actividad antiviral consistente y duradera de remdesivir "Estos resultados aportan pruebas de la actividad antiviral consistente y duradera de remdesivir en todas las variantes conocidas que han surgido a lo largo de la pandemia, incluida ómicron, y apoyan su uso continuado para el tratamiento de COVID-19 para las variantes actuales de SARS-CoV-2. Ahora que una nueva versión de ómicron (subvariante BA.2) está aumentando su circulación en todo el mundo, estos últimos datos también sugieren que remdesivir conservará la actividad antiviral contra esta nueva subvariante porque la ARN polimerasa viral a la que se dirige no contiene ninguna mutación única adicional. Gilead evalúa continuamente la actividad del antiviral contra las variantes virales", ha declarado el vicepresidente Senior de Investigación Virológica de Gilead Sciences, Tomas Cihlar.
Los resultados de este estudio se han presentado para su publicación en una revista revisada por pares y se han presentado como preprint en el servidor preimpresión 'BioRxiv'.
10 vídeos Cada año 1.500 niños son diagnosticados con cáncer en España Cuatro marineros muertos y varios desaparecidos en el naufragio de un pesquero gallego en Terranova Momento en el que un guepardo trata de atacar a un bebé de siete meses en un safari de Reino Unido Las imágenes del trágico accidente ferroviario en Múnich Canadá invoca "poderes de emergencia" para frenar las protestas de los antivacunas Las imágenes del accidente múltiple de Calella provocado por el granizo y que ha dejado 16 heridos Sale a fumar y es enguillido por el suelo Ucrania anuncia que la invasión rusa comenzará en 24 horas Radiografía de las bandas latinas en España Los primeros instantes de los investigadores en la casa del parricidio de Elche Cada año 1.500 niños son diagnosticados con cáncer en España Cuatro marineros muertos y varios desaparecidos en el naufragio de un pesquero gallego en Terranova Momento en el que un guepardo trata de atacar a un bebé de siete meses en un safari de Reino Unido Las imágenes del trágico accidente ferroviario en Múnich Canadá invoca "poderes de emergencia" para frenar las protestas de los antivacunas Las imágenes del accidente múltiple de Calella provocado por el granizo y que ha dejado 16 heridos Sale a fumar y es enguillido por el suelo Ucrania anuncia que la invasión rusa comenzará en 24 horas Radiografía de las bandas latinas en España Los primeros instantes de los investigadores en la casa del parricidio de Elche Cada año 1.500 niños son diagnosticados con cáncer en España Cuatro marineros muertos y varios desaparecidos en el naufragio de un pesquero gallego en Terranova Momento en el que un guepardo trata de atacar a un bebé de siete meses en un safari de Reino Unido Las imágenes del trágico accidente ferroviario en Múnich Canadá invoca "poderes de emergencia" para frenar las protestas de los antivacunas Las imágenes del accidente múltiple de Calella provocado por el granizo y que ha dejado 16 heridos Sale a fumar y es enguillido por el suelo Ucrania anuncia que la invasión rusa comenzará en 24 horas Radiografía de las bandas latinas en España Los primeros instantes de los investigadores en la casa del parricidio de Elche
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