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El CSIC descubre cómo detectar de forma precoz el cáncer de páncreas con un análisis de sangre Investigadores del CSIC han identificado un nuevo biomarcador de diagnóstico precoz para el cáncer de páncreas
Investigadores del CSIC han identificado un nuevo biomarcador de diagnóstico precoz para el cáncer de páncreas El hallazgo es clave ya que permite la detección a través de un análisis de sangre La proteína AXL es un marcador específico que indica que ya hay células malignas Investigadores del CSIC han identificado un nuevo biomarcador de diagnóstico precoz para el cáncer de páncreas más común, el adenocarcinoma ductal pancreático , que supone la tercera causa de muerte por cáncer en países desarrollados. El hallazgo es clave ya que permite la detección a través de un análisis de sangre y porque, hasta ahora, no existe ningún biomarcador para la detección temprana del cáncer de páncreas.
El hallazgo ha sido liderado por investigadores del Instituto Hospital del Mar de Investigaciones Médicas (IMIM-Hospital del Mar) y del Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC), centro del CSIC asociado al Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS).
El receptor tirosina-quinasa AXL, clave Publicado en la revista 'eBioMedicine ', el descubrimiento asocia la presencia de la proteína tirosina-quinasa AXL a la detección de este tipo de tumores. En el trabajo se ha analizado la utilidad del receptor tirosina-quinasa AXL, una proteína presente en la superficie de las células, para detectar la presencia de cáncer de páncreas. Esta proteína está habitualmente ausente en células normales, aunque si se observa notablemente en determinados tipos de tumores, como el pancreático.
"La proteína AXL es un marcador específico que nos indica que ya hay células malignas . El hecho de que este marcador esté vinculado a la célula en estadio tumoral, le da una gran importancia por su especificidad para diagnosticar el cáncer de páncreas", indica Pilar Navarro, investigadora del IIBB-CSIC y del IMIM-Hospital del Mar.
Solo el 20% se operan a tiempo Para demostrar la utilidad diagnóstica de este marcador mediante un análisis de sangre, los investigadores analizaron muestras de más de 200 pacientes con pancreatitis crónica y con tumores de páncreas. "De esta manera, se demostró la presencia de la proteína AXL soluble en sangre como marcador en los pacientes que ya habían desarrollado el tumor, sin estar presente ni en individuos sanos ni en los que sufrían pancreatitis crónica", destacan Neus Martínez-Bosch, investigadora del IMIM-Hospital del Mar y Helena Cristóbal, del IIBB (CSIC-IDIBAPS), co-primeras firmantes del trabajo.
Esta conclusión permite avanzar en la detección del cáncer de páncreas al identificar el tumor incluso en pacientes con pancreatitis , una patología que puede dificultar el diagnóstico. Así, se obtiene un nuevo marcador diagnóstico, una herramienta muy valiosa, puesto que la escasez de marcadores provoca que solo el 20 % de los pacientes se puedan operar a tiempo, propiciando la metástasis y la resistencia al tratamiento.
Este nuevo marcador supone una gran innovación en la detección de un tipo de cáncer para el que no existe ningún biomarcador de diagnóstico precoz. En la actualidad, se utiliza la proteína CA19-9 solo para evaluar la respuesta al tratamiento, pero no se puede usar en el diagnóstico a causa de su baja especificidad. "Por este motivo, disponer de una nueva herramienta es de especial relevancia, sobre todo teniendo en cuenta que el diagnóstico precoz es esencial para la cirugía del tumor, la única opción de tratamiento curativa", destaca Laura Visa, doctora en el Servicio de Oncología Médica del Hospital del Mar.
El futuro del estudio se relaciona con el análisis de los pacientes que se podrán beneficiar de este nuevo marcador, ya que un pequeño número de tumores de páncreas no expresan la proteína AXL. Sin embargo, la combinación del análisis de ambas proteínas, CA19-9 y AXL, determina la presencia de células cancerosas con una sensibilidad del 90 por ciento. "Estamos muy interesados en saber por qué algunos cánceres no expresan AXL, esto nos podría dar pistas para saber cómo funcionan los mecanismos tumorales que podríamos utilizar como dianas para tratamientos", concluye Pablo García de Frutos, investigador del IIBB (CSIC-IDIBAPS).
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